Killer-cell immunoglobulin-like receptor genotyping and HLA killer-cell immunoglobulin-like receptor-ligand identification by real-time polymerase chain reaction
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چکیده
منابع مشابه
Killer-cell immunoglobulin-like receptor genotyping and HLA killer-cell immunoglobulin-like receptor-ligand identification by real-time polymerase chain reaction.
The effector function of natural killer (NK) cells is modulated by surface expression of a range of killer-cell immunoglobulin-like receptors (KIRs) that interact with human leukocyte antigen (HLA) class I ligands. We describe the use of real-time polymerase chain reaction (PCR) assays that allow easy and quick detection of 16 KIR genes and the presence/absence of KIR-ligands based on allelic d...
متن کاملKiller-cell immunoglobulin-like receptor
INTRODUCTION During discussion at the WHO Nomenclature Committee for Factors of the HLA System meeting in Victoria, Canada, in May 2002, it was decided to form a subcommittee to coordinate the naming of alleles of the genes encoding the killer-cell immunoglobulin-like receptors (KIRs) [1]. These genes are encoded on chromosome 19 (19q13.4) and have varying degrees of polymorphism. The receptors...
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Background: The HLA class I molecules serve as ligands for both T cell receptors and killer cell immunoglobulin-like receptors (KIRs). Objective: We investigated the HLAC and HLA-Bw4 alleles as well as KIRs expression on CD56 positive lymphocytes to evaluate whether these genes and molecules could influence Ankylosing spondylitis (AS) susceptibility, alone or in combination. Methods: We typed 4...
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Natural killer (NK) cells are a subset of lymphocytes which play a crucial role in early innate immune response against infection and tumor transformation. Furthermore, they secrete interferon-γ (IFN-γ) and tumor necrosis factor (TNF) prompting adaptive immu-nity. NK cells distinguish the unhealthy cells from the healthy ones through an array of cell-surface receptors. Human NK cells use inhibi...
متن کاملinhibitory killer cell immunoglobulin-like receptor kir3dl1 in combination with hla-b bw4iso protect against ankylosing spondylitis
background: the hla class i molecules serve as ligands for both t cell receptors and killer cell immunoglobulin-like receptors (kirs). objective: we investigated the hlac and hla-bw4 alleles as well as kirs expression on cd56 positive lymphocytes to evaluate whether these genes and molecules could influence ankylosing spondylitis (as) susceptibility, alone or in combination. methods: we typed 4...
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ژورنال
عنوان ژورنال: Tissue Antigens
سال: 2011
ISSN: 0001-2815
DOI: 10.1111/j.1399-0039.2011.01749.x